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affects you, don drive or do other risky activities. You shouldn modify your routine until your doctor says you can. As outlined above, psychostimulant-induced dopamine release is responsible for reinforcing behaviors designed to seek and administer the drugs. The dopamine projections involved in this process are outlined in Figure 1 A, and as indicated, the most critical projection in this regard is the projection from the ventral tegmental area dopamine cells to the nucleus accumbens. 28-31 For example, if psychostimulant-induced release of dopamine in the nucleus accumbens is impaired, this affects the acquisition of drug-seeking behaviors, and can markedly influence the amount of drug taken in a well-trained subject. Thus, the learning of a task to obtain the drug and the amount of drug taken in a given session is strongly regulated by dopamine release in the accumbens. However, when an animal has been withdrawn from repeated psychostimulant use, and drug-seeking is initiated by an environmental stimulus such as a cue previously paired with drug delivery, or a novel stressor, it is dopamine release in the prefrontal cortex and amygdala, respectively, that mediates the reinstatement of drug-seeking. 32,33 Thus, relapse can be induced by dopamine release in prefrontal and allocortical brain regions, and reflects the aforementioned physiological role of dopamine release as a predictive antecendent to stimulus (drug) delivery. What this implies is that chronic release of dopamine by repeated psychostimulant administration may be modifying cortical and allocortical regulation of behavior. Dr. Chatterjee expands on this issue. ?he use of this kind of enhancement to try to help people get, whether it better grades or something else, is just part and parcel of that ultra competitive, winner?ake?ll environment, where if some people have a slight advantage, the belief is that it gives you disproportionate rewards.? CDC: “Attention-Deficit / Hyperactivity Disorder (ADHD): Treatment.” Selecting an Appropriate Testing Technique. Adderall narcolepsy treatment, doctors may begin with 5 mg a day and then go up to 60 mg a day,
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